ENDOSTATIN ALSO EFFECTIVE ON HEAD AND NECK CANCERS
Researchers at Ohio State found that endostatin has a dual effect on head and neck cancer cells – the compound prevented the cells from developing new blood vessels and also hindered the mechanism cancer cells use to migrate throughout the body and invade other tissues.
Head and neck cancers originate on the epithelium – the layer of tissue covering the outermost surfaces of the body, including the skin and mucus membranes. Kaposi’s sarcoma tumors arise from the endothelium, the cells that line blood vessels.
“The vast majority of endostatin studies have concentrated on endostatin’s effects against endothelial cells, and haven’t focused on the drug’s anti-tumorigenic possibilities,” said Susan Mallery, the study’s lead author and a professor in the Ohio State College of Dentistry’s department of oral and maxillofacial surgery and pathology.
“We wanted to explore other options for endostatin use,” she said.
After getting promising laboratory results with treating oral cavity tumor cells taken from men with oral cancer with endostatin, Mallery is suggesting the possibility of an implanted drug delivery system, one that could deliver endostatin directly to the site of a tumor after it was surgically removed.
“About half of all people with head and neck cancers die as a result of local disease recurrence,” Mallery said, adding that such cancers account for about 7 percent of all cancers in the United States. “Another major concern is patient compliance with follow-up treatment after the original tumor is removed.
“It’s possible that one day doctors could treat these patients with an implanted delivery device that dispenses a sustained, therapeutic drug concentration right where it is needed the most – where the tumor was,” she continued. “Such a treatment option not only provides a constant therapeutic drug level, it also eliminates concerns regarding patient compliance.”
In the current study, endostatin treatment reduced by half the number of invasive head and neck cancer cells, and also reduced the number of cells capable of migration by one-quarter. Migrating cells receive some sort of chemical signal before moving in a directed fashion throughout the body. Invasive cells migrate, but they also produce an enzyme that actually digests the membranes of the cells they’re trying to take over.
The research appears in a recent issue of the journal Anticancer Research.
Mallery and her colleagues received funding from the National Institutes of Health/National Institute of Dental and Craniofacial Research and from the Ohio Division of the American Cancer Society.