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(Last updated 10/28/04)
Website of the Ohio State
University-AAAS Fellows organization can be found here.
Previous stories citing faculty
named to Fellow status:
Honors Fifteen Ohio State Faculty With Rank Of Fellow,"
Honors Seven Faculty With Rank Of Fellow," 11/14/02.
AAAS HONORS FOURTEEN OHIO
STATE FACULTY WITH RANK OF FELLOW
COLUMBUS, Ohio – For the second year in a row, more Ohio State
University faculty members have earned the rank of Fellow from the American
Association for the Advancement of Science (AAAS) than any other single
institution this year.
With 14 faculty members ranking among the new 2004-05 AAAS Fellows,
Ohio State now boasts 90 Fellows.
“The fact that we’ve led the nation in new AAAS fellows
for two years in a row underscores the quality of our faculty and the
recognition of their success by their peers,” said President Karen
Holbrook, herself a AAAS Fellow.
“This honor is the latest indication of the increasing quality
and quantity of research that goes on at Ohio State,” said Robert
McGrath, senior vice president for research. “Coupled with the news
that the university received more than a half-billion dollars in research
funding during the last year, it is evident that the university has developed
a critical mass of nationally recognized scholars in a variety of disciplines
The new Fellows include:
- Barbara L. Andersen, professor of psychology,
“for distinguished contributions to the field of behavioral medicine,
particularly for studies in biobehavioral aspects of cancer and psychological
interventions for cancer patients.” Andersen heads the Stress
and Immunity Breast Cancer Project at Ohio State, which for the
past 10 years has been examining women with breast cancer to determine
if psychological and behavioral programs can help improve quality of
life and possibly prevent recurrence. Her studies have been among the
first to show that such interventions can lead to a stronger immune
system among breast cancer patients, which may have implications for
extending life. In addition, her research has shown that psychological
interventions can lead to important behavior changes among cancer patients,
such as healthier diets and reduced smoking.
- L. Mark Berliner, professor of statistics,
“for distinguished contributions to geophysical and environmental
statistics and for development of collaborative research among statisticians
and geophysical scientists.” Few scientists share Berliner’s
dual expertise in geophysics and statistics, but his development of
the first formal statistics program at the National
Center for Atmospheric Research has assured that others will follow.
He has designed unique computer models to quantify the uncertainty in
forecasts of climatic phenomena such as El Niño, and has brought
statistical insights to studies of global climate change.
- Ching-Shih Chen, professor of pharmacy
and internal medicine,
"for fundamental studies of lipid-mediated signal transduction
pathways in cancer and for discovery of novel therapeutic agents that
modulate cancer cell activation and death." Chen's work merges
synthetic organic chemistry with molecular and cellular biology to design
novel chemotherapy agents that attack molecular defects in tumor cells.
Currently, many of these promising compounds are undergoing tests at
different laboratories in the Ohio
State University Comprehensive Cancer Center to evaluate their effectiveness
against a number of cancers -- including prostate, breast, lung, pancreatic,
and ovarian cancers, and chronic lymphocytic leukemia.
- Russ Hille, professor of molecular
and cellular biochemistry, for "distinguished contributions
to enzymology, particularly with regard to the molecular structure and
mechanism of action of metalloenzymes that catalyze oxidation-reduction
reactions." By identifying each chemical step involved in enzymatic
reactions, Hille has helped unravel how an entire class of metal-containing
enzymes works. A better understanding of how enzymes work could make
it easier to design drugs that influence enzymatic activity in a desired
way to treat various diseases.
- Philip R. Johnson, the Henry G. Cramblett Chair
in Medicine; professor of pediatrics and molecular virology, immunology
and medical genetics; and president of the Columbus
Children's Research Institute, "for distinguished scientific
contributions to and leadership in the development of human immunodeficiency
virus vaccine and gene transfer technology for gene therapy." In
2003, Johnson's laboratory began testing an HIV vaccine in human clinical
trials. His work has also led to the development of a gene transfer
vector that is currently being used in clinical trials for cystic fibrosis
and rheumatoid arthritis at several centers in the United States.
- Yang Liu, Kurtz Chair Professor and director, Division
of Cancer Immunology, Department of Pathology;
professor of molecular virology, immunology and medical genetics; and
co-leader, Immunology Program of the Ohio State University Comprehensive
Cancer Center, “for fundamental studies relating innate immunity
to adaptive immunity, particularly in establishing the field of T cell
costimulation and studying tumor and immune response.” While all
plants and animals share the ability to repel invading bacteria and
viruses on a rudimentary chemical level, only humans and other highly
evolved vertebrates possess immune systems that are sophisticated enough
to produce customized antibodies or “killer T cells” to
mount a counterattack and maintain lasting immunity. Liu performed early
studies that proved these two types of immune systems are linked through
induction of costimulatory molecules. He is working to develop new methods
to help activate the body’s immune system in response to cancer,
while damping it in autoimmune diseases such as multiple sclerosis.
- Lawrence E. Mathes, professor of veterinary
biosciences; interim associate dean for research in the College
of Veterinary Medicine; and former director of OSU’s Center
for Retroviral Research, “for distinguished contributions
to retrovirus research, particularly in the understanding of viral pathogenesis
and the development of chemotherapy for feline leukemia virus and immunodeficiency
virus.” Mathes' research has provided critical knowledge of immunosuppressive
factors in retrovirus infections and neoplastic disease and he has a
long-standing interest in treatment and prevention of retrovirus disease.
He also has established a research program to evaluate anti-retrovirus
- Michael C. Ostrowski, professor of molecular
genetics, for "distinguished contributions to the field of
tumor biology, particularly in the elucidation of the role of signaling
molecules, oncogenes, and transcription factors in cancer." Ostrowski's
work has shed light on the wiring within cells that allows them to communicate
with other cells throughout the body, during both normal cell differentiation
as well as cancer progression. His research has helped to define how
this internal wiring -- called a signal transduction pathway -- gets
altered during cancer progression. Ostrowski played a pivotal role in
securing for Ohio State this year a nearly $9-million grant from the
National Cancer Institute to study
how genes in the tumor microenvironment -- the non-cancerous tissue
surrounding a tumor cell -- influence breast cancer progression.
- Electra Diane Paskett, Marion R. Rowley professor
of cancer research, College of Medicine
and Public Health; and associate director for population sciences
in the Comprehensive Cancer Center, "for distinguished contributions
to cancer control, in early detection amongst underserved and minority
populations, and for leadership roles in cancer control, population
sciences, and diversity enhancement." An internationally recognized
epidemiologist and expert on health issues that affect women and minorities,
Paskett focuses heavily on early detection as well as cancer prevention.
Through involvement in multiple cancer control studies, she has helped
design intervention strategies that persuade people to change their
behavior and take control of their health. She has spent a good portion
of her career working in poor, minority and underserved communities
in order to improve cancer screening rates.
- Thomas J. Rosol, professor of veterinary biosciences
and senior associate vice president for research, “for distinguished
contributions to endocrinology and bone pathobiology, particularly in
cancer-associated hypercalcemia and the pathogenesis of bone metastases
in mouse models of human cancer.” Both prostate cancer and breast
cancer metastasize to bones but the end disease can differ. Rosol’s
research programs are aimed at determining how those variations occur
and what approaches might be useful in reducing the migration of cancer.
Through the use of bioluminescence, he has developed an improved method
of producing images of tumors within animal models and is even exploring
the use of nanoparticles to enhance such images.
- Fred Sanfilippo, dean of the College of Medicine
and Public Health; senior vice president for health sciences; and chief
executive officer of the OSU Medical Center, “for distinguished
contributions to the field of transplantation immunology, while simultaneously
having a significant impact on enhancing medical research as a senior
administrator.” Before taking his current medical leadership post
as head of one of the country’s largest medical centers, Sanfilippo’s
research focused on the humoral mechanisms of rejection in xenotransplantation
and chronic graft vasculopathy, and on immunology and transplantation,
especially emphasizing renal and corneal transplants.
- Daniel R. Schoenberg, professor of molecular and
cellular biochemistry, for "fundamental studies of mRNA synthesis
and turnover, particularly for studies of RNA stability, translation
regulation, RNA-protein interaction, and genetic disorders of mRNA metabolism."
Schoenberg was the first to identify a class of enzymes called messenger
RNA (mRNA) endonucleases. These enzymes help control the overall amount
of mRNA in a cell, which in turn controls new protein synthesis. His
fundamental research on these enzymes led to the identification of the
molecular mechanism responsible for the defect in hemoglobin production
in beta-thalassemia, an inherited disease of red blood cell production.
- Altaf A. Wani, professor of radiology and molecular
and cellular biochemistry, and Director of the Molecular Carcinogenesis
Laboratory, “for distinguished contributions to the field of genomic
damage and repair, particularly repair regulation in human cells by
tumor suppressor p53 and its target proteins.” From exposures
to the sun’s ultraviolet light to cigarette smoke, many environmental
factors damage the DNA in our cells every day. Wani discovered that
the gene known as p53 participates in repairing such damage -- and is
critical for preventing the genetic mutations that lead to cancer development.
- Caroline C. Whitacre, professor and chair of molecular
virology, immunology and medical genetics, and associate vice president
for health sciences research within the Ohio State University Medical
Center, “for distinguished contributions to the field of neuroimmunology,
particularly the application of oral tolerance to autoimmunity and gender
differences in the incidence/progression of autoimmune disease.”
Whitacre’s laboratory uses both cellular and molecular approaches
to devise therapeutic regimens aimed at thwarting multiple sclerosis,
and focusing on the animal model, experimental autoimmune encephalomyelitis
(EAE). The primary focus of this research is to understand the mechanisms
underlying the disease suppression that can follow the oral administration
of an antigen (oral tolerance). The laboratory also studies the effects
of stress and central nervous system trauma on the immune system.
AAAS represents the world's largest federation of scientists and works
to advance science for human well being through its projects, programs
and publications. It conducts programs in the areas of science policy,
science education and international scientific cooperation. AAAS members
are elevated to the rank of Fellow for their efforts in advancing science
or fostering applications that are deemed scientifically or socially distinguished.
The association will publish the names of all 308 new Fellows in the
October 29 issue of the journal Science.
The Fellows will be honored in February 2005, during the AAAS
Annual Meeting in Washington, DC.
Contact: Robert McGrath, (614) 292-1582; Mcgrath.firstname.lastname@example.org
Written by Earle Holland, Jeff Grabmeier, Holly Wagner, and Pam Frost
Gorder, (614) 292-9475; Gorder.email@example.com